Valganciclovir thrice weekly for prophylaxis against cytomegalovirus reactivation during alemtuzumab therapy
نویسندگان
چکیده
منابع مشابه
Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy.
Alemtuzumab is an immunosuppressive antibody that depletes normal T cells and B cells. Prophylaxis for herpes virus and Pneumocystis carinii is standard with this agent. Approximately 20% to 25% of patients will experience cytomegalovirus (CMV) reactivation. We conducted a randomized trial wherein patients being treated with an alemtuzumab-containing regimen received prophylaxis with either val...
متن کاملCytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: incidence and treatment with oral ganciclovir.
BACKGROUND AND OBJECTIVES Although alemtuzumab (campath-1H) has been successfully used in patients with untreated or previously treated chronic lymphocytic leukemia (CLL), a variable incidence of cytomegalovirus (CMV) reactivation has been described. No prospective reports currently provide results of the use of oral ganciclovir as pre-emptive therapy in patients with CMV reactivation during al...
متن کاملValganciclovir versus valaciclovir for prevention of alemtuzumab-induced cytomegalovirus reactivation: what are the implications for routine clinical practice?
I read with interest the recently published study by O’Brien et al1 on valganciclovir versus valaciclovir in prevention of cytomegalovirus (CMV) reactivation in patients with lymphoid malignancies treated with alemtuzumab-containing regimens. The study was terminated early after enrollment of 40 patients due to CMV reactivation in 7 of 20 patiens on valaciclovir versus 0 of 20 on valganciclovir...
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2. Steinbrink K. T h e case for revislon arthroplasty u ing antibiotic-loaded acrylic cement. Clin Orthop Re1 Res 1990; 261: 19-22. 3. Gerhart TN, Roux RD, Hanff PA, Horowitz GL, Kenshaw AA, Hayes WC. Antibiotic-loaded biodegradable bone crmcnt for prophylaxis and treatment of experimental osteomyelitis in rats. J Orthop Res 19?3; 11: 250-5. 4. Reese RE, Betts RE Antibiotic use. In: Reese KE, B...
متن کاملValganciclovir prophylaxis against cytomegalovirus impairs lymphocyte proliferation and activation in renal transplant recipients.
BACKGROUND Antiviral prophylaxis against cytomegalovirus has been associated with reduced risk of allograft rejection and improved allograft survival after renal transplantation. This phenomenon might not be fully explained by preventing the indirect effects of cytomegalovirus. The effect of antiviral agents on lymphocyte function in patients treated with modern immunosuppression has not been s...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2008
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2008.282